Revascularization in Experimental Atherosclerotic Renal Artery Stenosis: Role of Mitochondrial Targeted Peptides (Bendavia)
نویسندگان
چکیده
Atherosclerotic Renal Artery Stenosis (ARAS) is a common cause of secondary hypertension, especially in the elderly population, and is often associated with increased cardiovascular morbidity and mortality, as well as progression to chronic renal insufficiency [1,2]. Consequently, treatment options have been increasingly directed towards the preservation of renal function and reduction in the progression to endstage renal disease (ESRD).
منابع مشابه
A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis.
Revascularization improves blood pressure but not renal function in most patients with atherosclerotic renal artery stenosis (ARAS), possibly related to injury incurred during renal reperfusion. Bendavia, a novel tetrapeptide that inhibits mitochondrial permeability transition pore opening, reduces apoptosis, oxidative stress, and ischemia-reperfusion injury in experimental models. However, its...
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